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KMID : 0828519970010010065
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Journal of the Korean Geriatrics Society
1997 Volume.1 No. 1 p.65 ~ p.70
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Utility of Serum Fructosamine as a Measure of Glycemia in Elderly Diabetic Patients
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Cho Young-Jung
Nam Hong-Woo
Moon Do-Ho
Doh Sung-Kyoung
Lee Seung-Bock
Jeong An-Chul
Yoo Hyung-Joon
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Abstract
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Background : Glycemic profile has traditionally been with the use of HbA1c over a 2 to 4 month period. Recently, serum fructosamine is highly sensitive to acute metabolic deterioration(period 2 to 3 weeks), and is suitable for automation, allowing multiple assays with minimal effort. In some report, despite evidence suggesting a reduction in serum albumin level with increasing age, serum fructosamine was strongly correlated with HbA1c in elderly diabetic patients. This study was conducted to define the correlation between fructosamine and other parameters in elderly diabetic patients.
Methods : The study group consisted of 56 elderly patients(age range : 66-85 years, group A) and 58 adult patients(age range: 18-64 years, group B), who were stable over recent 2 months in fasting glucose values and serum albumin levels. Fructosamine was measured in 114 diabetic patients. The measured levels were related to HbA1c and fructosamine/albumin index(FAI).
Results: 1) There was significant correlation between HbA1c and fructosamine in all diabetic patients(r=0.705, p= 0.0001). The correlation between HbA1c and fructosamine was stronger in group A than in group B [group A: r=0.831, group B: r=0.367, p=0.0001](p<0.05). 2) The correlation between HbA1c and FAI was significantly stronger compared to that between HbA1c and fructosamine in elderly diabetic patients(p<0.05). 3) Glycation ratio provides a vector-like insight into the recent trend of glycemia, and Glycation ratio was stable in all diabetic patients.
Conclusions : Our study suggests that correlation between HbA1c and fructosamine in elderly daibetic patients was significantly lower in adult diabetic patients. Further studies are needed to determine the ultimate values of this test in the clinical management of elderly patient with diabetes.
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KEYWORD
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Fructosamine, HbAlc, FAI
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